Asymmetric synthesis using organic catalysts has evolved since it was first realized and defined. Nowadays, it can be considered a valid alternative to transition metal catalysis for synthesizing chiral molecules. According to the literature, the number of asymmetric organocatalytic processes associated with atropisomer synthesis has rapidly increased over the past 10 years because organocatalysis addresses the challenges posed by the most widespread strategies used for preparing axially chiral molecules with satisfactory results.

中文翻译：

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金鸡纳生物碱在轴手性化合物的对映和非对映选择性合成中的作用

自首次实现和定义以来，使用有机催化剂的不对称合成得到了发展。如今，它可以被认为是合成手性分子的过渡金属催化的有效替代方法。根据文献，在过去 10 年中，与阻转异构体合成相关的不对称有机催化过程的数量迅速增加，因为有机催化解决了用于制备轴向手性分子的最广泛策略所带来的挑战，并取得了令人满意的结果。