A silver-catalyzed protocol for the synthesis of 3-(1H-isochromen)-chromones is described. The method involves an initial 6-endo-dig cyclization of o-alkynylbenzaldehydes and domino C−H alkylation and chromone annulation of the o-hydroxyarylenaminones, which enables the installation of 1H-isochromen and chromone in a single structure. This synthetic strategy is advantageous for the excellent regioselectivity, step economy, concise one-pot methodology, gram-scale synthesis, as well as high bond-forming efficiency.

中文翻译：

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Ag2O 催化邻羟基芳基氨基酮与邻炔基苯甲醛的级联环化反应合成功能化 3-(1H-异色烯)-色酮

描述了用于合成 3-(1 H- isochrome)-chromones 的银催化协议。该方法涉及邻炔基苯甲醛的初始 6-内切环化和多米诺 C-H 烷基化以及邻羟基芳基氨基酮的色酮环化，这使得 1 H-等色烯和色酮能够安装在单一结构中。该合成策略具有出色的区域选择性、步骤经济性、简洁的一锅法、克级合成以及高成键效率等优点。