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Continuous Flow Chemistry Synthesis of Spirocyclic Sultams and Isoquinolines through Rhodium-Catalyzed C−H Activation.
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2022-11-30 , DOI: 10.1002/ejoc.202201170
Ting Zheng, Meng-Ling Lin, Lin Dong

Continuous flow technology has been applied to C−H activation to improve reaction efficiency. Various imines and alkynes have been smoothly applied to continuous flow system, and the spirocyclic sultams and isoquinolines can be obtained in excellent yields in a relatively short time via [3+2] or [4+2] annulation reactions.

中文翻译:

通过铑催化的 C−H 活化连续流动化学合成螺环磺胺和异喹啉。

连续流动技术已应用于C-H活化以提高反应效率。各种亚胺和炔烃已顺利应用于连续流系统,通过[3+2]或[4+2]环化反应可在相对较短的时间内以优异的收率获得螺环磺胺和异喹啉。
更新日期:2022-11-30
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