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Boosting Simultaneous Uranium Decorporation and Reactive Oxygen Species Scavenging Efficiency by Lacunary Polyoxometalates
ACS Applied Materials & Interfaces ( IF 9.5 ) Pub Date : 2022-12-01 , DOI: 10.1021/acsami.2c11226 Peiheng Shi 1 , Xiaomei Wang 1 , Hailong Zhang 1 , Qiwen Sun 1 , Ao Li 1 , Yu Miao 1 , Cen Shi 1 , Jingwen Guan 1 , Shicheng Gong 1 , Juan Diwu 1
ACS Applied Materials & Interfaces ( IF 9.5 ) Pub Date : 2022-12-01 , DOI: 10.1021/acsami.2c11226 Peiheng Shi 1 , Xiaomei Wang 1 , Hailong Zhang 1 , Qiwen Sun 1 , Ao Li 1 , Yu Miao 1 , Cen Shi 1 , Jingwen Guan 1 , Shicheng Gong 1 , Juan Diwu 1
Affiliation
The chemical toxicity and the oxidative stress induced by the internal exposure of uranium is responsible for the long-term adverse effect of in vivo contamination of uranium. An agent with simultaneous removal capability of uranium and excess reactive oxygen species (ROS) is highly desired. Herein, the lacunary Keggin-type polyoxometalate (POM) is demonstrated to selectively bind with uranyl ions in the presence of excess essential divalent ions and exhibits a compelling ROS scavenging efficiency of 78.8%. In vivo uranium decorporation assays illustrate the uranium sequestration efficiencies of 74.0%, 49.4%, and 37.1% from kidneys by prophylactic, prompt, and delayed administration of lacunary POM solution, respectively. The superior ROS quenching and uranium removal performance in comparison with all reported bifunctional agents endow lacunary polyoxometalates as novel agents to effectively protect people from injuries caused by the internal exposure of actinides.
中文翻译:
通过缺位多金属氧酸盐提高同时铀装饰和活性氧物种清除效率
铀的内部暴露引起的化学毒性和氧化应激是造成铀体内污染的长期不利影响的原因。非常需要一种能够同时去除铀和过量活性氧 (ROS) 的试剂。在此,空缺的 Keggin 型多金属氧酸盐 (POM) 被证明在存在过量必需二价离子的情况下选择性地与铀酰离子结合,并表现出令人信服的 78.8% 的 ROS 清除效率。体内铀装饰测定表明,通过预防、及时和延迟给予腔隙 POM 溶液,肾脏的铀封存效率分别为 74.0%、49.4% 和 37.1%。
更新日期:2022-12-01
中文翻译:
通过缺位多金属氧酸盐提高同时铀装饰和活性氧物种清除效率
铀的内部暴露引起的化学毒性和氧化应激是造成铀体内污染的长期不利影响的原因。非常需要一种能够同时去除铀和过量活性氧 (ROS) 的试剂。在此,空缺的 Keggin 型多金属氧酸盐 (POM) 被证明在存在过量必需二价离子的情况下选择性地与铀酰离子结合,并表现出令人信服的 78.8% 的 ROS 清除效率。体内铀装饰测定表明,通过预防、及时和延迟给予腔隙 POM 溶液,肾脏的铀封存效率分别为 74.0%、49.4% 和 37.1%。