Liquidliquid extraction as a detoxification process can increase productivity and product titers from lignocellulosic biomass fermentable sugars while leading to inhibitors recovery for further upgrading in sustainable chemical platforms. In this study, 14 solvents were investigated for inhibitors compounds removal. In addition to solvent solubility in hemicellulosic hydrolysate (HH) and distribution coefficients, solvent biocompatibility with S. passalidarum was determined. Considering all solvents evaluated, methyl isobutyl ketone (MIBK) showed good acetic acid (35%), furfural (42%), phenolic (35%), hydroxymethylfurfural (76%), and formic acid (18%) extraction. The medium presented lower HH solubility (0.93 ± 0.08 g_sol L_HH⁻¹), which provided an ethanol yield (82.2 ± 0.6%), and productivity (0.90 ± ≤ 0.1 g_EtOH L⁻¹ h⁻¹) higher than those of the synthetic media (control) (79.6 ± 0.3% and 0.89 ± ≤ 0.1 g_EtOH L⁻¹ h⁻¹). In addition, preliminary evaluation of the solvent health-safety-environment pointed to MIBK as one of the solvents with the least impacts on climate change and human toxicity.

液液萃取作为解毒过程可以提高木质纤维素生物质可发酵糖的生产率和产品效价，同时导致抑制剂回收以进一步升级可持续化学平台。在这项研究中，研究了 14 种溶剂去除抑制剂化合物的效果。除了溶剂在半纤维素水解产物 (HH) 中的溶解度和分配系数外，还确定了与S. passalidarum的溶剂生物相容性。考虑到评估的所有溶剂，甲基异丁基酮 (MIBK) 显示出良好的乙酸 (35%)、糠醛 (42%)、酚醛 (35%)、羟甲基糠醛 (76%) 和甲酸 (18%) 萃取效果。介质呈现出较低的 HH 溶解度 (0.93 ± 0.08 g _sol L _HH ^-1)，其乙醇产量 (82.2 ± 0.6%) 和生产率 (0.90 ± ≤ 0.1 g _EtOH L ⁻¹ h ⁻¹ ) 高于合成培养基（对照）（79.6 ± 0.3% 和 0.89 ± ≤ 0.1） g _EtOH L ^-1 h ^-1 )。此外，对溶剂健康-安全-环境的初步评估表明，MIBK 是对气候变化和人体毒性影响最小的溶剂之一。