Tumor recurrence after hepatic resection is a severe challenge of current liver cancer treatment. Here we present novel multicomponent microspheres (MCMs) with co-encapsulation and spatiotemporal drug release capabilities for post-surgical liver cancer treatment and liver regeneration. The MCMs were fabricated via a stepwise microfluidic platform and were composed of a sodium alginate (ALG) shell and gelatin methacrylate (GelMA) cores. Benefitting from the “particle-in-particle” structure, the MCMs provided the possibility of loading doxorubicin (DOX) and augmenter of liver regeneration (ALR) into the shell and the cores, respectively. Besides, the MCMs enabled rapid release of DOX and more sustained release of ALR. Therefore, the dual-drug-loaded MCMs exhibited prominent effects of postsurgical tumor killing and promoting liver regeneration. We anticipate that the present MCMs have remarkable potentials as versatile drug delivery systems for post-surgical cancer therapy.

肝切除术后肿瘤复发是当前肝癌治疗面临的严峻挑战。在这里，我们展示了具有共包封和时空药物释放能力的新型多组分微球 (MCM)，用于肝癌术后治疗和肝再生。MCM 通过逐步微流体平台制造，由海藻酸钠 (ALG) 壳和明胶甲基丙烯酸酯 (GelMA) 核组成。受益于“粒子中粒子”结构，MCMs 提供了将阿霉素 (DOX) 和肝再生促进剂 (ALR) 分别加载到壳和核中的可能性。此外，MCM 能够快速释放 DOX 和更持久地释放 ALR。因此，双载药MCM表现出显着的术后肿瘤杀伤和促进肝再生的作用。