当前位置: X-MOL 学术Chem. Eng. J. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Lyophilization-inactivated cancer cells composited Janus scaffold for tumor postoperative immuno-chemotherapy
Chemical Engineering Journal ( IF 15.1 ) Pub Date : 2022-11-28 , DOI: 10.1016/j.cej.2022.140619
Gaizhen Kuang, Qingfei Zhang, Yunru Yu, Xiaoya Ding, Weijian Sun, Xian Shen, Yuanjin Zhao

Immunotherapy has played an important role in the treatment of malignant tumors. Efforts in this area are focused on exploiting a facile scaffold-based cancer vaccine with admirable efficacy and favorable property for tumor immunotherapy. Herein, an implantable sponge-nanofiber Janus scaffold with lyophilization-inactivated cancer cells, immune adjuvant imiquimod, and 5-fluorouracil (5-FU) spatially loading has been developed for tumor postoperative immuno-chemotherapy. The inactivated cancer cells and imiquimod encapsulated macroporous sponge of the scaffold can act as an immune niche to initiate a potent immune response. While the 5-FU loaded nanofibers can not only enhance the mechanical property of the scaffold, but also increase the anti-tumor immunity of the scaffold by directly killing cancer cells and depleting myeloid-derived suppressor cells to remodel the tumor immunosuppression microenvironment. Based on these features, the excellent anti-recurrence and anti-metastasis efficiency of the composited Janus scaffold have been demonstrated in the mouse breast tumor model. Thus, it is convinced that the proposed Janus scaffold spatially encapsulated with lyophilization-inactivated cancer cell vaccines and chemotherapeutic agents will provide novel sights for combination therapy after tumor surgery.



中文翻译:

冻干灭活癌细胞复合Janus支架用于肿瘤术后免疫化疗

免疫疗法在恶性肿瘤的治疗中发挥了重要作用。该领域的工作重点是开发一种简便的基于支架的癌症疫苗,该疫苗具有令人钦佩的功效和对肿瘤免疫治疗有利的特性。在此,开发了一种具有冻干灭活癌细胞、免疫佐剂咪喹莫特和 5-氟尿嘧啶 (5-FU) 空间负载的可植入海绵纳米纤维 Janus 支架,用于肿瘤术后免疫化疗。灭活的癌细胞和支架的咪喹莫特包裹的大孔海绵可以作为免疫生态位来启动有效的免疫反应。而负载 5-FU 的纳米纤维不仅可以增强支架的机械性能,但也通过直接杀死癌细胞和消耗髓源性抑制细胞来重塑肿瘤免疫抑制微环境来增加支架的抗肿瘤免疫力。基于这些特点,在小鼠乳腺肿瘤模型中证明了复合 Janus 支架优异的抗复发和抗转移效率。因此,相信所提出的 Janus 支架空间封装有冻干灭活的癌细胞疫苗和化学治疗剂将为肿瘤手术后的联合治疗提供新的视角。

更新日期:2022-12-01
down
wechat
bug