With the increasing demand for biomimetic structures in the biomedical field, ultrafast lasers have been extensively used for modifying the surfaces of alloy thin films. Herein, we propose a method entailing the use of picosecond laser ablation for modifying the surfaces of chromium–Ti nitride (CrTiN) thin films for cell culture processes. The surface roughness and ripple characteristics of the periodic corrugated nanopod structures formed on these films were effectively controlled by controlling the laser fluence. The surface roughness and contact angles of ripple structures were affected by the laser fluence, and the mechanical and electrochemical properties of these structures could be improved by appropriately controlling the laser fluence. The wetting behaviors of the prepared CrTiN thin films with different roughness values were affected by the laser–material interaction. Furthermore, the periodic corrugated nanopod structures on these films enhanced the proliferation and viability of A549 cells on the films. This paper provides an alternative method for growing cells on surfaces with periodic microstructures or nanostructures. The proposed method has the potential for use in the development of new microcomposites or nanocomposites and in-vivo detection in biomedical applications.

随着生物医学领域对仿生结构的需求不断增加，超快激光已被广泛用于合金薄膜的表面修饰。在此，我们提出了一种需要使用皮秒激光烧蚀来修改用于细胞培养过程的铬-氮化钛 (CrTiN) 薄膜表面的方法。通过控制激光能量密度，可以有效地控制在这些薄膜上形成的周期性波纹纳米荚结构的表面粗糙度和波纹特性。波纹结构的表面粗糙度和接触角受激光能量密度的影响，通过适当控制激光能量密度可以改善这些结构的机械和电化学性能。所制备的具有不同粗糙度值的 CrTiN 薄膜的润湿行为受激光-材料相互作用的影响。此外，这些薄膜上的周期性波纹纳米荚结构增强了 A549 细胞在薄膜上的增殖和活力。本文提供了一种在具有周期性微结构或纳米结构的表面上生长细胞的替代方法。所提出的方法有可能用于开发新的微型复合材料或纳米复合材料以及生物医学应用中的体内检测。