We describe herein a novel synthesis of various homoallylic nitriles via cobalt-catalyzed hydrocyanation of methylenecyclopropanes. Excellent selectivity, mild reaction conditions, good functional group compatibility, gram-scale reaction, and product transformations demonstrate the power of this protocol. This extraordinary selectivity can probably be attributed to the stronger aptitude of the alkyl–cobalt cyanide intermediate to undergo reductive elimination rather than β-hydride elimination.

中文翻译：

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钴催化亚甲基环丙烷氢氰化生成同型烯丙基腈

我们在此描述了一种通过亚甲基环丙烷的钴催化氢氰化反应合成各种同型烯丙基腈的新方法。出色的选择性、温和的反应条件、良好的官能团相容性、克级反应和产物转化证明了该协议的强大功能。这种非凡的选择性可能归因于烷基-氰化钴中间体进行还原消除而不是 β-氢化物消除的能力更强。