The SARS-CoV-2 Omicron (B.1.1.529) variant has been associated with less severe acute disease, however, concerns remain as to whether long-term complaints persist to a similar extent as for earlier variants. Studying 1 323 145 persons aged 18-70 years living in Norway with and without SARS-CoV-2 infection in a prospective cohort study, we found that individuals infected with Omicron had a similar risk of post-covid complaints (fatigue, cough, heart palpitations, shortness of breath and anxiety/depression) as individuals infected with Delta (B.1.617.2), from 14 to up to 126 days after testing positive, both in the acute (14 to 29 days), sub-acute (30 to 89 days) and chronic post-covid (≥90 days) phases. However, at ≥90 days after testing positive, individuals infected with Omicron had a lower risk of having any complaint (43 (95%CI = 14 to 72) fewer per 10,000), as well as a lower risk of musculoskeletal pain (23 (95%CI = 2-43) fewer per 10,000) than individuals infected with Delta. Our findings suggest that the acute and sub-acute burden of post-covid complaints on health services is similar for Omicron and Delta. The chronic burden may be lower for Omicron vs Delta when considering musculoskeletal pain, but not when considering other typical post-covid complaints.

SARS-CoV-2 Omicron (B.1.1.529) 变体与不太严重的急性疾病有关，但是，人们仍然担心长期抱怨的持续程度是否与早期变体相似。在一项前瞻性队列研究中，研究了 1 323 145 名生活在挪威的 18-70 岁感染和未感染 SARS-CoV-2 的人，我们发现感染 Omicron 的人有相似的 covid 后投诉风险（疲劳、咳嗽、心脏心悸、呼吸急促和焦虑/抑郁）作为感染 Delta (B.1.617.2) 的个体，在检测呈阳性后 14 至 126 天，急性（14 至 29 天）、亚急性（30至 89 天）和慢性新冠后（≥90 天）阶段。然而，在检测呈阳性后≥90 天，感染 Omicron 的人有任何投诉的风险较低（每 10,000 人减少 43（95%CI = 14 至 72）），以及肌肉骨骼疼痛的风险较低（每 10,000 人减少 23（95%CI = 2-43） 10,000) 比感染 Delta 的个体多。我们的研究结果表明，对于 Omicron 和 Delta，新冠疫情后对医疗服务的投诉所带来的急性和亚急性负担是相似的。在考虑肌肉骨骼疼痛时，Omicron 与 Delta 的慢性负担可能较低，但在考虑其他典型的 covid 后投诉时则不然。