Sake (a traditional Japanese alcoholic beverage) contains ethyl caproate (EC), which enhances its economic value. Isovaleraldehyde (IVA) is also a well-known flavoring agent in alcoholic beverages, which some people enjoy. Recently, studies revealed that EC decreased the size of homogenous 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes whereas IVA increased their size. Cholesterol (Chol) and ergosterol were previously referred to as animal and fungus sterols. For the first time, this study demonstrated the phase behavior of the membrane in cell-sized liposomes containing EC and IVA. After adding EC, the solid ordered/liquid disordered (Ld) and liquid ordered (Lo)/Ld phase separation in DOPC/dipalmitoyl-sn-glycero-3-phosphocholine/cholesterol or ergosterol ternary membranes decreased, but the Lo/Ld phase separation decreased after adding IVA. Biophysics, physiological, and application aspects of EC and IVA evaluation were discussed. The findings of this study not only enhance our understanding of the function of flavors but also provide rapid and cost effective performance for the measurement.

中文翻译：

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含清酒香料的细胞模型膜的相分离结构

清酒（一种传统的日本酒精饮料）含有己酸乙酯 (EC)，可提高其经济价值。异戊醛 (IVA) 也是酒精饮料中众所周知的调味剂，有些人喜欢它。最近，研究表明 EC 减小了同质 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) 脂质体的大小，而 IVA 增加了它们的大小。胆固醇 (Chol) 和麦角甾醇以前被称为动物和真菌甾醇。这项研究首次展示了细胞大小的含有 EC 和 IVA 的脂质体中膜的相行为。添加EC后，DOPC/二棕榈酰-sn-甘油-3-磷酸胆碱/胆固醇或麦角甾醇三元膜中的固体有序/液体无序（Ld）和液体有序（Lo）/Ld相分离减少，但加入 IVA 后 Lo/Ld 相分离减少。讨论了 EC 和 IVA 评估的生物物理学、生理学和应用方面。这项研究的结果不仅增强了我们对香料功能的理解，而且还为测量提供了快速且具有成本效益的性能。