Trends in Cognitive Sciences ( IF 19.9 ) Pub Date : 2022-11-24 , DOI: 10.1016/j.tics.2022.11.003 Genela Morris 1 , Dori Derdikman 2
Place cells and grid cells are major building blocks of the hippocampal cognitive map. The prominent forward model postulates that grid-cell modules are generated by a continuous attractor network; that a velocity signal evoked during locomotion moves entorhinal activity bumps; and that place-cell activity constitutes summation of entorhinal grid-cell modules. Experimental data support the first postulate, but not the latter two. Several families of solutions that depart from these postulates have been put forward. We suggest a modified model (spatial modulation continuous attractor network; SCAN), whereby place cells are generated from spatially selective nongrid cells. Locomotion causes these cells to move the hippocampal activity bump, leading to movement of the entorhinal manifolds. Such inversion accords with the shift of hippocampal thought from navigation to more abstract functions.
中文翻译:
网格单元和位置单元的先有鸡还是先有蛋的问题
位置细胞和网格细胞是海马认知地图的主要组成部分。突出的正向模型假设网格单元模块是由连续吸引子网络生成的;在运动过程中诱发的速度信号会移动内嗅活动颠簸;并且该位置细胞活动构成了内嗅网格细胞模块的总和。实验数据支持第一个假设,但不支持后两个。已经提出了几个偏离这些假设的解决方案系列。我们建议修改模型(空间调制连续吸引子网络;扫描),其中位置单元格是从空间选择性非网格单元格生成的。运动导致这些细胞移动海马体活动隆起,导致内嗅歧管运动。