Integration of functional micro-/nano-frameworks with various analytical techniques is favored to produce advanced and practical methods for identification, inspection, and regulation of hazards in agro-food products. Herein, two novel synthetic strategies were developed for preparation of core–shell structured ZIF-8@COF by using metal halides as the catalyst, and further construction of hollow-structured covalent organic frameworks (HCOFs) with a sacrificial template method. The HCOFs adsorbent exhibited high stability, universality and adsorption affinity for advanced glycation end products (AGEs) and aflatoxins (AFTs) than pristine COF. Combined with HPLC and HPLC-MS/MS, the applicability of this method was verified by infant formula samples with satisfying recoveries of 87.3%–98.9%. Furthermore, HCOF showed potential ability of adsorbing and removing AGEs from plasma without causing other risk. This work opens up the road for further research on the simple method to synthesis HCOF, besides, provides a technological basis for monitoring and controlling AGEs and AFTs in milk powder.

中文翻译：

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ZIF-8 牺牲模板中空 COF 架构能够高效富集、测定和监管婴儿配方奶粉中的食品危害

将功能性微/纳米框架与各种分析技术相结合，有利于产生先进实用的农产品危害识别、检查和监管方法。在此，开发了两种新颖的合成策略，以金属卤化物为催化剂制备核壳结构的ZIF-8@COF，并通过牺牲模板法进一步构建中空结构的共价有机框架（HCOF）。与原始 COF 相比，HCOF 吸附剂对晚期糖基化终末产物 (AGE) 和黄曲霉毒素 (AFT) 表现出较高的稳定性、通用性和吸附亲和力。结合HPLC和HPLC-MS/MS，通过婴儿配方奶粉样品验证了该方法的适用性，回收率令人满意，为87.3%~98.9%。此外，HCOF 显示出从血浆中吸附和去除 AGE 的潜在能力，且不会造成其他风险。该工作为进一步研究HCOF的简单合成方法开辟了道路，并为奶粉中AGEs和AFTs的监测和控制提供了技术基础。