In different organs and tissues, the lymphatic system serves as a drainage system for interstitial fluid and is useful for removing substances that would otherwise accumulate in the interstitium. In the brain, which lacks lymphatic circulation, the drainage and cleaning function is performed by the glymphatic system, called so for its dependence on glial cells and its similar function to that of the lymphatic system. In the present article, we define glymphatic insufficiency as the inability of the glymphatic system to properly perform the brain cleaning function. Furthermore, we propose that corpora amylacea or wasteosomes, which are protective structures that act as waste containers and accumulate waste products, are, in fact, a manifestation of chronic glymphatic insufficiency. Assuming this premise, we provide an explanation that coherently links the formation, distribution, structure, and function of these bodies in the human brain. Moreover, we open up new perspectives in the study of the glymphatic system since wasteosomes can provide information about which variables have the greatest impact on the glymphatic system and which diseases occur with chronic glymphatic insufficiency. For example, based on the presence of wasteosomes, it seems that aging, sleep disorders, and cerebrovascular pathologies have the highest impact on the glymphatic system, whereas neurodegenerative diseases have a more limited impact. Furthermore, as glymphatic insufficiency is a risk factor for neurodegenerative diseases, information provided by wasteosomes could help to define the strategies and actions that can prevent glymphatic disruptions, thus limiting the risk of developing neurodegenerative diseases.

中文翻译：

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废物体（淀粉体）作为慢性淋巴细胞功能不全的标志

在不同的器官和组织中，淋巴系统充当间质液的引流系统，可用于去除否则会积聚在间质中的物质。在缺乏淋巴循环的大脑中，引流和清洁功能由淋巴系统执行，因其依赖神经胶质细胞及其与淋巴系统相似的功能而得名。在本文中，我们将淋巴系统功能不全定义为淋巴系统无法正确执行大脑清洁功能。此外，我们建议淀粉体或废物体是充当废物容器并积累废物的保护性结构，实际上是慢性淋巴细胞功能不全的表现。假设这个前提，我们提供了一种解释，将这些身体在人脑中的形成、分布、结构和功能联系起来。此外，我们开辟了 glymphatic 系统研究的新视角，因为废物体可以提供有关哪些变量对 glymphatic 系统影响最大以及慢性 glymphatic 功能不全会发生哪些疾病的信息。例如，基于废物体的存在，似乎衰老、睡眠障碍和脑血管病变对淋巴系统的影响最大，而神经退行性疾病的影响更为有限。此外，