Proteins are one of the dynamic macromolecules that play a significant role in many physiologically important processes to sustain life on the earth. Proteins need to be properly folded into their active conformation to perform their function. Alteration in the protein folding process may lead to the formation of misfolded conformers. Accumulation of these misfolded conformers can result in the formation of protein aggregates which are attributed to many human pathological conditions including neurodegeneration, cataract, neuromuscular disorders, and diabetes. Living cells naturally have heterogeneous crowding environments with different concentrations of various biomolecules. Macromolecular crowding condition has been found to alter the protein conformation. Here in this review, we tried to show the relation between macromolecular crowding, protein aggregation, and its consequences.

蛋白质是动态大分子之一，在维持地球生命的许多重要生理过程中发挥着重要作用。蛋白质需要正确折叠成其活性构象才能发挥其功能。蛋白质折叠过程的改变可能导致错误折叠的构象异构体的形成。这些错误折叠的构象异构体的积累会导致蛋白质聚集体的形成，这归因于许多人类病理状况，包括神经变性、白内障、神经肌肉疾病和糖尿病。活细胞自然具有异质的拥挤环境，其中含有不同浓度的各种生物分子。已发现大分子拥挤条件会改变蛋白质构象。在这篇综述中，我们试图展示大分子拥挤之间的关系，