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Single-particle electrophoresis for studying the adsorption of cationic polymers onto anionic particles
Electrophoresis ( IF 2.9 ) Pub Date : 2022-11-22 , DOI: 10.1002/elps.202200209
Íngrid Amer Cid 1 , Lenny Van Daele 2 , Peter Dubruel 2 , Kristiaan Neyts 1 , Filip Strubbe 1
Affiliation  

Understanding the adsorption of polymers onto particles is crucial for many technological and biomedical applications. Even though polymer adsorption on particles is a dynamic process, most experimental techniques can only study the adsorption indirectly, in equilibrium and on the ensemble level. New analysis methods are required to overcome these limitations. We investigated the use of single-particle electrophoresis to study the adsorption kinetics of cationic polymers onto anionic particles and compared the resulting data to a theoretical model. In this approach, the electrophoretic mobility of single polystyrene (PS) particles, exposed to different concentrations of poly(2-guanidinoethyl methacrylate), was measured as a function of time. The polymer adsorption leads to an electrophoretic mobility change of the PS particle over time, from the initial negative value to a positive value at equilibrium. By fitting the kinetics data to the Langmuir model, the adsorption rate, desorption rate and equilibrium constant were determined. Finally, the adsorption kinetics of several other polymers was investigated. This showed that the presented technique enables direct analysis and comparison of the kinetics of polymer adsorption on the single-particle level.

中文翻译:

单粒子电泳研究阳离子聚合物在阴离子粒子上的吸附

了解聚合物在颗粒上的吸附对于许多技术和生物医学应用至关重要。尽管聚合物在颗粒上的吸附是一个动态过程,但大多数实验技术只能在平衡和整体水平上间接研究吸附。需要新的分析方法来克服这些限制。我们研究了使用单粒子电泳来研究阳离子聚合物在阴离子粒子上的吸附动力学,并将所得数据与理论模型进行比较。在这种方法中,单个聚苯乙烯 (PS) 颗粒暴露于不同浓度的聚(甲基丙烯酸 2-胍基乙酯)的电泳迁移率随时间的变化而变化。聚合物吸附导致 PS 粒子的电泳迁移率随时间发生变化,从初始负值到平衡时的正值。通过将动力学数据拟合到 Langmuir 模型,确定了吸附速率、解吸速率和平衡常数。最后,研究了几种其他聚合物的吸附动力学。这表明所提出的技术能够直接分析和比较聚合物在单粒子水平上的吸附动力学。
更新日期:2022-11-22
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