Dual detection concepts (DDCs) are becoming more and more popular in analytical chemistry. In this work, we describe a novel DDC for capillary electrophoresis (CE) consisting of an amperometric detector (AD) and a mass spectrometer (MS). This detector combination has a good complementarity as the AD exhibits high sensitivity, whereas the MS provides excellent selectivity. Both detectors are based on a destructive detection principle, making a serial detector arrangement impossible. Thus, for the realization of the DDC, the CE flow was divided into two parts with a flow splitter. The DDC was characterized in a proof-of-concept study with ferrocene derivates and a nonaqueous background electrolyte. We could show that splitting the CE flow was a suitable method for the instrumental realization of the DDC consisting of two destructive detectors. By lowering the height of the AD compared to the MS, it was possible to synchronize the detector responses. Additionally, for the chosen model system, we confirmed that the AD was much more reproducible and had lower limits of detection (LODs) than the MS. The LODs were identical for the DDC and the single-detection arrangements, indicating no sensitivity decrease due to the CE flow splitting. The DDC was successfully applied to determine the drug and doping agent trimetazidine.

中文翻译：

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结合电流分析法和质谱法作为毛细管电泳的双重检测方法

双检测概念 (DDC) 在分析化学中变得越来越流行。在这项工作中，我们描述了一种用于毛细管电泳 (CE) 的新型 DDC，由安培检测器 (AD) 和质谱仪 (MS) 组成。这种检测器组合具有良好的互补性，因为 AD 表现出高灵敏度，而 MS 提供出色的选择性。两种检测器均基于破坏性检测原理，使得串联检测器布置成为不可能。因此，为了实现 DDC，CE 流被分流器分成两部分。DDC 在使用二茂铁衍生物和非水背景电解质的概念验证研究中进行了表征。我们可以证明，拆分 CE 流是一种适合仪器实现由两个破坏性检测器组成的 DDC 的方法。与 MS 相比，通过降低 AD 的高度，可以同步检测器响应。此外，对于所选的模型系统，我们确认 AD 比 MS 具有更高的重现性和更低的检测限 (LOD)。DDC 和单一检测装置的 LOD 相同，表明 CE 分流不会导致灵敏度降低。DDC成功应用于药物和掺杂剂曲美他嗪的测定。表明 CE 分流不会导致灵敏度降低。DDC成功应用于药物和掺杂剂曲美他嗪的测定。表明 CE 分流不会导致灵敏度降低。DDC成功应用于药物和掺杂剂曲美他嗪的测定。