Presented herein is a method for the construction of indolizine-based heterocyclic sulfonyl fluorides through [3 + 2] cycloaddition of isoquinolinium/quinolinium salts and 1-bromoethene-1-sulfonyl fluoride (BESF), driven by Et₃N and 4,5-dichloro-3,6-dioxocyclohexa-1,4-diene-1,2-dicarbonitrile (DDQ). This transformation features mild conditions, high efficiency, easily obtained starting materials, and broad substrate scope, providing a great potential value in medicinal chemistry and other related disciplines.

中文翻译：

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[3 + 2]环加成组装中氮杂环磺酰氟

本文介绍了一种通过异喹啉/喹啉盐和 1-溴乙烯-1-磺酰氟 (BESF) 的 [3 + 2] 环加成反应构建中氮杂环磺酰氟的方法，该方法由 Et ₃ N 和 4,5-驱动dichloro-3,6-dioxocyclohexa-1,4-diene-1,2-dicarbonitrile (DDQ)。该转化条件温和、效率高、起始原料易得、底物适用范围广，在药物化学及相关学科中具有巨大的潜在价值。