The artificial construction of multicomponent supramolecular materials comprising plural supramolecular architectures that are assembled orthogonally from their constituent molecules has attracted growing attention. Here, we describe the design and development of multicomponent supramolecular materials by combining peptide-based self-assembled fibrous nanostructures with globular DNA nanoflowers constructed by the rolling circle amplification reaction. The orthogonally constructed architectures were dissected by fluorescence imaging using the selective fluorescence staining procedures adapted to this study. The present, unique hybrid materials developed by taking advantage of each supramolecular architecture based on their peptide and DNA functions may offer distinct opportunities to explore their bioapplications as a soft matrix.

中文翻译：

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由基于肽的超分子纳米纤维和通过滚环扩增原位生成的 DNA 纳米花组成的超分子杂化纳米材料的设计

由多个超分子结构组成的多组分超分子材料的人工构建，这些结构由其组成分子正交组装而成，引起了越来越多的关注。在这里，我们通过将基于肽的自组装纤维纳米结构与通过滚环扩增反应构建的球状 DNA 纳米花相结合，描述了多组分超分子材料的设计和开发。使用适用于本研究的选择性荧光染色程序，通过荧光成像对正交构造的结构进行解剖。目前，通过利用基于肽和 DNA 功能的每个超分子结构开发的独特混合材料可能提供独特的机会来探索其作为软基质的生物应用。