A continuous flow organocatalytic synthesis of formamides has been developed using amines and CO₂ reaction partners in the presence of a silane reductant. The process is conducted under comparatively mild reaction conditions and allows the preparation of a broad family of N-substituted formamides in good yield. The heterogenized catalyst is a PS-supported superbase (DBU), while (MeO)₃SiH proved to be the most efficient reductant. The reaction was first optimized in batch mode, giving access to fifteen different N-substituted formamide products. The optimized conditions were then used as input to develop a proof-of-concept continuous flow process based on the model substrate N-phenyl aniline thereby providing N-methyl-N-phenyl formamide as target with good productivity.

中文翻译：

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CO2 间歇和连续流有机催化胺的 N-甲酰化

在硅烷还原剂存在下，使用胺和 CO ₂反应伴侣开发了甲酰胺的连续流动有机催化合成。该过程在相对温和的反应条件下进行，并允许以良好的产率制备广泛的N-取代甲酰胺。多相催化剂是 PS 负载的超级碱 (DBU)，而 (MeO) ₃ SiH 被证明是最有效的还原剂。首先以分批模式优化反应，获得十五种不同的N-取代甲酰胺产物。然后将优化条件用作输入，以开发基于模型基板N的概念验证连续流过程-苯基苯胺从而以良好的生产率提供N-甲基-N-苯基甲酰胺作为目标。