Poly(amino ester)s (PAEs) refer to a class of synthetic polymers characterized by repeating units in the backbone having tertiary amines and ester bonds, and bringing together the inherent biodegradability of polyesters and the rich tunable functionalities provided by tertiary amines. The presence of tertiary amines allows the introduction of various pendant groups, leading to diverse PAE material and properties, such as biodegradability, biocompatibility, water-solubility, stimulus-responsiveness (pH or temperature), etc. To date, PAEs are evolving into a new class of biodegradable polymer materials independent of aliphatic polyesters and have been widely used in various biomedical fields, such as gene delivery, drug delivery, bioimaging agents, etc. In addition, a new family of PAEs, namely N-acylated PAEs, with the same pendant carbonyl groups as poly(2-oxazoline)s, is expected to develop into new biopolymer platforms similar to polypeptoids and polyoxazolines. This review comprehensively summarizes the synthesis methods of PAEs, including polycondensation (PCD), Michael addition polymerization (MAP), spontaneous zwitterionic copolymerization (SZWIP), and ring-opening polymerization (ROP).

聚（氨基酯）（PAE）是指一类合成聚合物，其特征在于主链中的重复单元具有叔胺和酯键，并将聚酯固有的生物降解性和叔胺提供的丰富可调官能团结合在一起。叔胺的存在允许引入各种侧基，导致不同的 PAE 材料和特性，例如生物降解性、生物相容性、水溶性、刺激响应性（pH 或温度）等。迄今为止，PAE 正在演变为独立于脂肪族聚酯的一类新型生物可降解高分子材料，已广泛应用于各种生物医学领域，如基因传递、药物传递、生物显像剂等。此外，一个新的 PAE 家族，即N-酰化 PAEs 与聚（2-恶唑啉）具有相同的羰基侧基，有望发展成类似于多肽和聚恶唑啉的新型生物聚合物平台。本综述全面总结了 PAE 的合成方法，包括缩聚 (PCD)、迈克尔加成聚合 (MAP)、自发两性离子共聚 (SZWIP) 和开环聚合 (ROP)。