Ulcerative colitis (UC) is becoming an increasingly serious health problem. This study aimed to investigate the effect of a newly isolated Lactobacillus species that produces feruloyl esterase (FAEb) on dextran sodium sulfate (DSS)-induced UC in mice. In this study, FAEb supplementation slowed body weight loss and mitigated colon length shortening, the severity of fecal occult blood, and increases in the disease activity index (DAI) in UC model mice. FAEb supplementation was also shown to reduce the expression of proinflammatory factors, increase the antioxidant capacity, improve the production of beneficial short-chain fatty acids (SCFAs), upregulate the expression of tight junction proteins, reduce the histopathological scores, and reduce mucous barrier damage in the gut. Furthermore, FAEb supplementation was shown to inhibit inflammatory NF-κB signaling pathway activity, increase the abundance of beneficial bacteria, and regulate the balance of microbiota in the gut. These results suggest that FAEb may serve as a potential probiotic to prevent and treat UC.

中文翻译：

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产阿魏酸酯酶乳酸杆菌对葡聚糖硫酸钠诱导的小鼠溃疡性结肠炎的影响

溃疡性结肠炎 (UC) 正成为一个日益严重的健康问题。本研究旨在研究新分离的乳酸杆菌的作用在葡聚糖硫酸钠 (DSS) 诱导的小鼠 UC 上产生阿魏酸酯酶 (FAEb) 的物种。在这项研究中，FAEb 补充剂减缓了 UC 模型小鼠的体重减轻并减轻了结肠长度的缩短、粪便潜血的严重程度以及疾病活动指数 (DAI) 的增加。FAEb 补充剂还被证明可以减少促炎因子的表达，增加抗氧化能力，提高有益的短链脂肪酸 (SCFAs) 的产生，上调紧密连接蛋白的表达，降低组织病理学评分，减少粘膜屏障损伤在肠道里。此外，补充 FAEb 可抑制炎症性 NF-κB 信号通路活性，增加有益细菌的丰度，并调节肠道微生物群的平衡。