In the present paper, biodegradable hybrid hydrogels were prepared by using chitosan as a natural polymer and polyurethane containing azomethine as a synthetic polymer for the drug delivery application for 5-fluorouracil. The fabricated hydrogels were characterized via FT-IR and SEM analysis. Besides, the thermal, mechanical, and wettability properties, water uptake, biodegradation, protein absorption, drug loading, and release behaviors of the hybrid hydrogels were studied. The obtained results indicated that the fabricated hybrid hydrogels have exhibited good mechanical, hydrophilic, water uptake, and biodegradation behaviors. The hybrid hydrogels also showed 50% drug release amounts and they could be a good candidate for the controlled delivery of 5-FU due to these properties.

中文翻译：

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用于药物输送的基于壳聚糖的混合水凝胶：制备、生物降解、热和机械性能

在本论文中，以壳聚糖为天然聚合物，以含有偶氮甲碱的聚氨酯为合成聚合物，制备了可生物降解的杂化水凝胶，用于 5-氟尿嘧啶的药物递送应用。通过 FT-IR 和 SEM 分析对制造的水凝胶进行表征。此外，还研究了杂化水凝胶的热、机械和润湿性、吸水性、生物降解性、蛋白质吸收、药物负载和释放行为。所得结果表明，制备的杂化水凝胶表现出良好的机械、亲水、吸水和生物降解行为。混合水凝胶还显示出 50% 的药物释放量，由于这些特性，它们可能是 5-FU 受控递送的良好候选者。