A lipid nanoparticles-mediated, enzyme-triggered signal amplification strategy was proposed for precise miRNA imaging both in vitro and in vivo. The combination of switchable catalytic hairpin assembly with controlled in vivo delivery enables tumor-specific signal amplification with reduced off-tumor signal.

中文翻译：

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由脂质纳米颗粒递送的酶门控催化发夹组件用于 miRNA 成像中信号放大的肿瘤特异性激活

提出了一种脂质纳米粒子介导的、酶触发的信号放大策略，用于体外和体内精确的 miRNA 成像。可切换的催化发夹组件与受控的体内递送相结合，可实现肿瘤特异性信号放大，同时减少肿瘤外信号。