当前位置: X-MOL 学术Chem. Mater. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Accelerated Preparation of Polypeptides and Related Hybrid Materials from a Disintegrable Initiator Array with Masked Carbenium Precursors
Chemistry of Materials ( IF 8.6 ) Pub Date : 2022-11-15 , DOI: 10.1021/acs.chemmater.2c02913
Zehong Cheng, Jing Guo, Jia Pan, Ying Liu, Huan Wei, Jishan Li, Song Liu, Yuanyuan Hu, Yugang Bai

We report a disintegrable initiator array for the synthesis of well-defined polypeptides using raw N-carboxyanhydride monomers that are purified in situ. Free polypeptides can be obtained through the superfast disintegration of the initiation system after polymerization, simultaneously revealing unmasked, highly active benzhydrylium (BHD) ends for efficient conjugation. The polypeptide synthesis and conjugation combined can be accomplished in 3.5 h starting from amino acids. The high activity of BHD on the polypeptides can be utilized to construct complex hybrid materials with ease, shown in two proof-of-concept examples. The BHD-capped polypeptide presents the first reported case of the polymer being used as a dopant, which grafts onto and dopes poly(3-hexylthiophene) directly to give biocompatible, conductive polypeptide brushes. In addition, such polypeptides can directly decorate two-dimensional MoS2 nanosheets for significantly improved dispersibility and activity as a heterogeneous catalyst.

中文翻译:

使用掩蔽碳正离子前体从可崩解引发剂阵列加速制备多肽和相关杂化材料

我们报告了一种可分解​​的引发剂阵列,用于使用原位纯化的原始N-羧酸酐单体合成定义明确的多肽. 可以通过聚合后引发系统的超快速分解获得游离多肽,同时显示未掩蔽的高活性二苯甲基 (BHD) 末端以实现有效结合。从氨基酸开始,多肽合成和结合可以在 3.5 小时内完成。BHD 对多肽的高活性可用于轻松构建复杂的杂化材料,如两个概念验证示例所示。BHD 封端的多肽首次报道了聚合物用作掺杂剂的案例,该聚合物直接接枝并掺杂聚(3-己基噻吩)以提供生物相容性导电多肽刷。此外,此类多肽还可以直接修饰二维 MoS 2纳米片作为多相催化剂可显着提高分散性和活性。
更新日期:2022-11-15
down
wechat
bug