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Biomotors, Viral Assembly, And Rna Nanobiotechnology: Current Achievements And Future Directions
Computational and Structural Biotechnology Journal ( IF 6 ) Pub Date : 2022-11-11 , DOI: 10.1016/j.csbj.2022.11.007
Lewis Rolband 1 , Damian Beasock 1 , Yang Wang 2 , Yao-Gen Shu 2 , Jonathan D Dinman 3 , Tamar Schlick 4 , Yaoqi Zhou 5 , Jeffrey S Kieft 6 , Shi-Jie Chen 7 , Giovanni Bussi 8 , Abdelghani Oukhaled 9 , Xingfa Gao 10 , Petr Šulc 11 , Daniel Binzel 12 , Abhjeet S Bhullar 12 , Chenxi Liang 12 , Peixuan Guo 12 , Kirill A Afonin 1
Affiliation  

The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent advancements, a biennial discussion focused on biomotors, viral assembly, and RNA nanobiotechnology has been established where international experts in interdisciplinary fields such as structural biology, biophysical chemistry, nanotechnology, cell and cancer biology, and pharmacology share their latest accomplishments and future perspectives. The results summarized here highlight advancements in our understanding of viral biology and the structure-function relationship of frame-shifting elements in genomic viral RNA, improvements in the predictions of SHAPE analysis of 3D RNA structures, and the understanding of dynamic RNA structures through a variety of experimental and computational means. Additionally, recent advances in the drug delivery, vaccine design, nanopore technologies, biomotor and biomachine development, DNA packaging, RNA nanotechnology, and drug delivery are included in this critical review. We emphasize some of the novel accomplishments, major discussion topics, and present current challenges and perspectives of these emerging fields.



中文翻译:

生物马达、病毒组装和 RNA 纳米生物技术:当前成就和未来方向

国际 RNA 纳米技术和纳米医学协会 (ISRNN) 致力于进一步开发各种功能性核酸和其他相关纳米技术平台。为了帮助传播最新进展,每两年举行一次讨论,重点关注生物马达、病毒组装和 RNA 纳米生物技术,结构生物学、生物物理化学、纳米技术、细胞和癌症生物学以及药理学等跨学科领域的国际专家参加分享他们的最新成就和未来展望。这里总结的结果强调了我们对病毒生物学和基因组病毒 RNA 中移码元件的结构功能关系的理解的进步,3D RNA 结构 SHAPE 分析预测的改进,以及通过各种实验和计算手段了解动态 RNA 结构。此外,本次重要综述还包括药物输送、疫苗设计、纳米孔技术、生物马达和生物机器开发、DNA 包装、RNA 纳米技术和药物输送方面的最新进展。我们强调一些新颖的成就、主要讨论主题,并提出这些新兴领域当前的挑战和观点。

更新日期:2022-11-11
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