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RNAME: a comprehensive database of RNA modification enzymes
Computational and Structural Biotechnology Journal ( IF 6 ) Pub Date : 2022-11-11 , DOI: 10.1016/j.csbj.2022.11.022
Fulei Nie 1, 2 , Qiang Tang 3, 4 , Ying Liu 2 , Huaizhi Qin 2 , Shilong Liu 2 , Meng Wu 2 , Pengmian Feng 3 , Wei Chen 1, 2, 3, 4
Affiliation  

The dynamic RNA modifications were orchestrated by a series of enzymes, namely “writer”, “reader” and “eraser”, which can install, recognize and remove the modifications, respectively. However, only a very small number of experimentally validated RNA modification enzymes have been identified and reported. Therefore, there is an urgent need to develop a database to deposit RNA modification enzymes. In the present work, we developed the RNAME database (https://chenweilab.cn/rname/) to provide a comprehensive resource for RNA modification enzymes. The current version of RNAME deposits more than 21,000 manually curated RNA modification enzymes, which are from 456 species and covers the 7 common kinds of RNA modifications (i.e., adenosine to inosine, N1-methyladenosine, N6-methyladenosine, 5-methylcytidine, N7-methylguanosine, mRNA cap modification, and pseudouridine). The 3D structures, domains, subcellular locations, and biological functions of these enzymes were also integrated in RNAME. It is anticipated that RNAME will facilitate the researches on RNA modifications.



中文翻译:

RNAME:RNA修饰酶的综合数据库

动态 RNA 修饰由一系列酶协调,即“写入器”、“读取器”和“擦除器”,它们可以分别安装、识别和删除修改。然而,只有极少数经过实验验证的 RNA 修饰酶得到鉴定和报道。因此,迫切需要开发一个数据库来存放RNA修饰酶。在目前的工作中,我们开发了 RNAME 数据库 (https://chenweilab.cn/rname/),为 RNA 修饰酶提供全面的资源。当前版本的 RNAME 存放了超过 21,000 个人工精选的 RNA 修饰酶,它们来自 456 个物种,涵盖了 7 种常见的 RNA 修饰(即腺苷到肌苷、N 1 -甲基腺苷、N 6-甲基腺苷、5-甲基胞苷、N 7 -甲基鸟苷、mRNA 帽修饰和假尿苷)。这些酶的 3D 结构、结构域、亚细胞位置和生物学功能也被整合到 RNAME 中。预计 RNAME 将促进 RNA 修饰的研究。

更新日期:2022-11-11
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