Surface plasmon resonance biosensors are drawing attention due to their real-time, label-free, and rapid characteristic. To detect trace biomarkers (ct-DNA, mi-RNA, PD-L1), plasmonic and metal oxide nanoparticles have been utilized for signal amplification and have shown exciting results. To achieve uniform, reproducible, simple, and sensitive sensor interface construction, two-dimensional materials such as graphene and molybdenum sulfide have opened a research upsurge and show a great possibility in the surface plasmon resonance biosensing field due to their unique large specific surface area, excellent in-plane electron transport effect, and singular optical properties. Here, we provide an overview of the recent research progress on two-dimensional materials in the field of surface plasmon resonance biosensors, including the optoelectronic properties of two-dimensional materials, sensitivity enhancement mechanism, and interface construction. Finally, the challenges and development directions of detection sensitivity enhancement are summarized and prospected. Our work will provide a useful platform to expand the further application of two-dimensional materials in surface plasmon resonance biosensors.

中文翻译：

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基于二维纳米材料的表面等离子体共振生物传感器界面修饰研究进展

表面等离子体共振生物传感器由于其实时、无标记和快速的特性而受到关注。为了检测痕量生物标志物（ct-DNA、mi-RNA、PD-L1），等离子体和金属氧化物纳米粒子已被用于信号放大并显示出令人兴奋的结果。为了实现均匀、可重复、简单、灵敏的传感器界面构建，石墨烯和硫化钼等二维材料以其独特的大比表面积开启了研究热潮，并在表面等离子体共振生物传感领域显示出巨大的可能性，优异的面内电子传输效应和奇异的光学特性。在此，我们综述了二维材料在表面等离子共振生物传感器领域的最新研究进展，包括二维材料的光电特性、灵敏度增强机制、界面构建等。最后总结并展望了检测灵敏度增强面临的挑战和发展方向。我们的工作将为扩大二维材料在表面等离子体共振生物传感器中的进一步应用提供一个有用的平台。