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Schizophrenia, Curcumin and Minimizing Side Effects of Antipsychotic Drugs: Possible Mechanisms
Neurochemical Research ( IF 4.4 ) Pub Date : 2022-11-10 , DOI: 10.1007/s11064-022-03798-4
Reyhaneh Rabiee 1 , Saeedeh Hosseini Hooshiar 2 , Amir Ghaderi 3 , Sadegh Jafarnejad 2
Affiliation  

Schizophrenia is a mental disorder characterized by episodes of psychosis; major symptoms include hallucinations, delusions, and disorganized thinking. More recent theories focus on particular disorders of interneurons, dysfunctions in the immune system, abnormalities in the formation of myelin, and augmented oxidative stress that lead to alterations in brain structure. Decreased dopaminergic activity and increased phospholipid metabolism in the prefrontal cortex might be involved in schizophrenia. Antipsychotic drugs used to treat schizophrenia have many side effects. Alternative therapy such as curcumin (CUR) can reduce the severity of symptoms without significant side effects. CUR has important therapeutic properties such as antioxidant, anti-mutagenic, anti-inflammatory, and antimicrobial functions and protection of the nervous system. Also, the ability of CUR to pass the blood–brain barrier raises new hopes for neuroprotection. CUR can improve and prevent further probable neurological and behavioral disorders in patients with schizophrenia. It decreases the side effects of neuroleptics and retains lipid homeostasis. CUR increases the level of brain-derived neurotrophic factor and improves hyperkinetic movement disorders. CUR may act as an added counteraction mechanism to retain cell integrity and defense against free radical injury. Thus it appears to have therapeutic potential for improvement of schizophrenia. In this study, we review several properties of CUR and its ability to improve schizophrenia and minimize the side effects of antipsychotic drugs, and we explore the underlying mechanisms by which CUR affects schizophrenia and its symptoms.



中文翻译:

精神分裂症、姜黄素和最小化抗精神病药物的副作用:可能的机制

精神分裂症是一种以精神病发作为特征的精神障碍;主要症状包括幻觉、妄想和思维混乱。最近的理论侧重于中间神经元的特定疾病、免疫系统功能障碍、髓磷脂形成异常以及导致大脑结构改变的氧化应激增加。前额皮质中多巴胺能活性降低和磷脂代谢增加可能与精神分裂症有关。用于治疗精神分裂症的抗精神病药物有许多副作用。姜黄素 (CUR) 等替代疗法可以减轻症状的严重程度,而没有明显的副作用。CUR 具有重要的治疗特性,例如抗氧化、抗诱变、抗炎和抗菌功能以及保护神经系统。还,CUR 通过血脑屏障的能力为神经保护带来了新的希望。CUR 可以改善和预防精神分裂症患者进一步可能出现的神经和行为障碍。它减少精神安定药的副作用并保持脂质稳态。CUR 增加脑源性神经营养因子的水平并改善多动性运动障碍。CUR 可以作为一种额外的反作用机制来保持细胞完整性和防御自由基损伤。因此,它似乎具有改善精神分裂症的治疗潜力。在这项研究中,我们回顾了 CUR 的几个特性及其改善精神分裂症和最大限度减少抗精神病药物副作用的能力,并探讨了 CUR 影响精神分裂症及其症状的潜在机制。

更新日期:2022-11-11
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