DNA repair enzymes continuously provide surveillance throughout our cells, protecting the enclosed DNA from the damage that is constantly arising from oxidation, alkylating species, and radiation. Members of this enzyme class are intimately linked to pathways controlling cancer and inflammation and are promising targets for diagnostics and future therapies. Their study is benefiting widely from the development of new tools and methods aimed at measuring their activities. Here, we provide an Account of our laboratory’s work on developing chemical tools to study DNA repair processes in vitro, as well as in cells and tissues, and what we have learned by applying them.

中文翻译：

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用于研究 DNA 修复的化学工具

DNA 修复酶持续监视我们的整个细胞，保护封闭的 DNA 免受氧化、烷基化物质和辐射不断引起的损害。这类酶的成员与控制癌症和炎症的途径密切相关，是诊断和未来治疗的有希望的目标。他们的研究广泛受益于旨在衡量他们活动的新工具和方法的开发。在这里，我们介绍了我们实验室在开发化学工具以研究体外以及细胞和组织中的 DNA 修复过程方面所做的工作，以及我们通过应用它们所学到的知识。