当前位置: X-MOL 学术Org. Chem. Front. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Photo-induced nickel-mediated cross-electrophile coupling for alkylated allenes via electron donor–acceptor complexes
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2022-11-09 , DOI: 10.1039/d2qo01623k
Zhao-Zhao Zhou, Xiao-Feng Zhai, Shu-Liang Zhang, Ke-Jian Xia, Haixin Ding, Xian-Rong Song, Wan-Fa Tian, Yong-Min Liang, Qiang Xiao

Herein, a highly regioselective alkylation of propargylic carbonates for trisubstituted allenes with alkyl N-hydroxyphthalimide (NHP) esters was developed via a nickel-mediated radical cross-electrophile coupling process. Electron donor–acceptor (EDA) complex photoactivation strategies have emerged as a versatile way for alkyl radicals. This method features mild conditions and a broad substrate scope and the involvement of primary alkyl radicals represents the first direct approach for primary alkylated allenes. Preliminary mechanistic studies indicated that this transformation proceeded through a radical–radical coupling process.

中文翻译:

通过电子供体-受体复合物光诱导镍介导的烷基化丙二烯交叉亲电试剂偶联

在此,通过镍介导的自由基交叉亲电偶联过程,开发了用烷基N-羟基邻苯二甲酰亚胺 (NHP) 酯对三取代丙二烯的炔丙基碳酸酯进行高度区域选择性烷基化。电子供体-受体 (EDA) 复合物光活化策略已成为烷基自由基的通用方法。该方法具有温和的条件和广泛的底物范围,伯烷基自由基的参与代表了伯烷基化丙二烯的第一种直接方法。初步的机理研究表明,这种转变是通过自由基-自由基偶联过程进行的。
更新日期:2022-11-09
down
wechat
bug