A concise total synthesis of (±)-pileamartines A and B, a pair of alkaloids sharing an unprecedented tetracyclic skeleton, was achieved in 9 and 8 linear steps, respectively. The key steps include an NHC-catalyzed tandem aza-benzoin/Michael reaction to rapidly establish the polyhydroindenopyrrole core, a diastereoselective reductive allylation of pyrrolidone, and an RCM to construct the piperidine ring.

中文翻译：

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(±)-pileamartines A 和 B 的简明全合成

(±)-pileamartines A 和 B 的简明全合成，一对生物碱具有前所未有的四环骨架，分别在 9 和 8 个线性步骤中实现。关键步骤包括 NHC 催化的串联氮杂-安息香/Michael 反应以快速建立聚氢茚并吡咯核、吡咯烷酮的非对映选择性还原烯丙基化和 RCM 以构建哌啶环。