Mixing double-hydrophilic block copolymers containing a poly(vinylphosphonic acid) block with gadolinium ions in water leads to the spontaneous formation of polymeric nanoparticles. With an average diameter near 20 nm, the nanoparticles are stable after dilution or change of pH and ionic strength. High magnetic relaxivities were measured in vitro, and in vivo magnetic resonance imaging on rats demonstrates the high potential of such polymeric assemblies.

中文翻译：

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钆离子组装聚（乙烯基膦酸）基双亲水嵌段共聚物用于形成高度稳定的 MRI 造影剂

将含有聚（乙烯基膦酸）嵌段的双亲水嵌段共聚物与水中的钆离子混合会导致聚合物纳米粒子的自发形成。平均直径接近 20 nm，纳米粒子在稀释或 pH 值和离子强度变化后稳定。在体外测量了高磁弛豫，并且在大鼠体内磁共振成像证明了这种聚合物组装体的高潜力。