Abstract

Liquidambarines A − C (1−3), three new abietane-type diterpenoids, together with five known compounds (4−8) were isolated from the resin of Liquidambar formosana Hance. Their structures were elucidated by the combination of spectroscopic and computational methods. We explored their anti-inflammatory potential by analyzing the protein expression of iNOS and COX-2. Compounds 1 and 3 exhibit significant anti-inflammatory activities without cytotoxicity. These experimental studies suggest these new abietane-type diterpenoids have the potential to be candidates for inflammation-associated diseases.

中文翻译：

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枫香碱 A – C、枫香中的三种新松香烷二萜及其抗炎活性

摘要

从枫香树脂中分离得到枫香素 A − C ( 1 − 3 )，三种新的松香烷型二萜类化合物，以及五种已知化合物 ( 4 − 8 ) 。通过光谱和计算方法的结合阐明了它们的结构。我们通过分析 iNOS 和 COX-2 的蛋白表达来探索它们的抗炎潜力。化合物1和3表现出显着的抗炎活性而没有细胞毒性。这些实验研究表明这些新的松香烷型二萜类化合物有可能成为炎症相关疾病的候选药物。