Chlorinated paraffins (CPs) are high production volume plasticizers and flame retardants, which have exhibited bioaccumulative and toxic properties. CPs may be released from treated consumer goods and bind with indoor dust, leading to human exposure via unintentional dust ingestion. In this study, the concentrations and homologue distribution of CPs were measured in 50 indoor dust samples collected in paired winter and summer sampling campaigns from 25 homes in Flanders, Belgium. Short-, medium- and long-chain CPs (SCCPs (C_10-13), MCCPs (C_14-17) and LCCPs (C_18-20), respectively) were each detected in all Belgian indoor dust samples with overall median concentrations of 6.1 µg/g (range 0.61 to 120 µg/g), 45 µg/g (range 4.5 to 520 µg/g) and 4.5 µg/g (range 0.3 to 50 µg/g), respectively. Concentrations were significantly higher in the winter samples than summer for each of the three groups (p < 0.05). LCCPs homologues ranging from C_21-32 were also detected in dust samples and accounted for approximately half of the LCCP relative abundance based on instrumental peak area, although a lack of appropriate analytical standards prevented quantification of these homologues. While clear sources of CP contamination in dust could not be identified, significant associations between concentrations of ∑SCCPs, ∑MCCPs and ∑LCCPs (C_18-20) (p < 0.05) suggested the combined application within materials or products in homes. Based on typical exposure scenarios, estimated daily intake of ∑CPs (C_10-20) for adults and toddlers were 14 and 270 ng/kg bw/day, respectively, though margin of exposure assessments for SCCPs and MCCPs indicated that adverse health effects were unlikely for all exposure scenarios. This study presents the first evidence of seasonal variation in the levels and distribution for each of the SCCP, MCCP and LCCP classes in indoor dust and highlights the urgent need for appropriate analytical standards for LCCP quantification.

氯化石蜡 (CP) 是高产量增塑剂和阻燃剂，具有生物蓄积性和毒性。氯化石蜡可能会从经过处理的消费品中释放出来，并与室内灰尘结合，从而导致人类通过无意吸入灰尘而接触到这些物质。在这项研究中，测量了从比利时佛兰德斯的 25 个家庭收集的 50 个室内灰尘样本中 CP 的浓度和同系物分布，这些样本是在成对的冬季和夏季采样活动中收集的。短链、中链和长链氯化石蜡 (SCCPs (C _10-13 )、中链氯化石蜡 (C _14-17 ) 和长链氯化石蜡 (C _18-20)，分别在所有比利时室内灰尘样本中分别检测到，总中值浓度分别为 6.1 µg/g（范围 0.61 至 120 µg/g）、45 µg/g（范围 4.5 至 520 µg/g）和 4.5 µg/g （范围分别为 0.3 至 50 µg/g）。对于三组中的每一组，冬季样本中的浓度显着高于夏季样本 ( p  < 0.05)。在灰尘样品中也检测到范围从 C _21-32的 LCCP 同系物，并且占基于仪器峰面积的 LCCP 相对丰度的大约一半，尽管缺乏适当的分析标准阻止了这些同系物的量化。虽然无法确定灰尘中 CP 污染的明确来源，但 ∑SCCPs、∑MCCPs 和 ∑LCCPs 的浓度之间存在显着关联 (C _18-20) ( p  < 0.05) 建议在家庭材料或产品中进行组合应用。根据典型的接触情景，估计成人和幼儿的 ∑CPs (C _10-20 ) 每日摄入量分别为 14 和 270 ng/kg bw/天，尽管 SCCPs 和 MCCPs 的接触边际评估表明不利的健康影响是不太可能适用于所有暴露场景。本研究首次提供了室内灰尘中 SCCP、MCCP 和 LCCP 类别的水平和分布季节性变化的证据，并强调了对 LCCP 量化的适当分析标准的迫切需求。