As an important member of ion channels family, the voltage-gated sodium channel (VGSC/Nav) is associated with a variety of diseases, including epilepsy, migraine, ataxia, etc., and has always been a hot target for drug design and discovery. Many subtype-selective modulators targeting VGSCs have been reported, and some of them have been approved for clinical applications. However, the drug design resources related to VGSCs are insufficient, especially the lack of accurate and extensive compound data toward VGSCs. To fulfill this demand, we develop the Voltage-gated Sodium Channels Database (VGSC-DB). VGSC-DB is the first open-source database for VGSCs, which provides open access to 6055 data records, including 3396 compounds from 173 references toward nine subtypes of Navs (Nav1.1 ~ Nav1.9). A total of 28 items of information is included in each data record, including the chemical structure, biological activity (IC50/EC50), target, binding site, organism, chemical and physical properties, etc. VGSC-DB collects the data from small-molecule compounds, toxins and various derivatives. Users can search the information of compounds by text or structure, and the advanced search function is also supported to realize batch query. VGSC-DB is freely accessible at http://cadd.zju.edu.cn/vgsc/ , and all the data can be downloaded in XLSX/SDF file formats.

中文翻译：

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VGSC-DB：电压门控钠通道在线数据库

作为离子通道家族的重要成员，电压门控钠通道（VGSC/Nav）与多种疾病相关，包括癫痫、偏头痛、共济失调等，一直是药物设计和发现的热门靶点. 已经报道了许多针对 VGSC 的亚型选择性调节剂，其中一些已被批准用于临床应用。然而，与 VGSCs 相关的药物设计资源不足，尤其是缺乏针对 VGSCs 的准确和广泛的化合物数据。为了满足这一需求，我们开发了电压门控钠通道数据库 (VGSC-DB)。VGSC-DB 是 VGSCs 的第一个开源数据库，它提供对 6055 条数据记录的开放访问，包括来自 173 个参考文献的 3396 种化合物，用于 9 个 Navs 子类型（Nav1.1 ~ Nav1.9）。每条数据记录共包含28项信息，包括化学结构、生物活性（IC50/EC50）、靶点、结合位点、生物体、化学和物理性质等。VGSC-DB从小型-分子化合物、毒素和各种衍生物。用户可以通过文本或结构来搜索化合物的信息，还支持高级搜索功能，实现批量查询。VGSC-DB可在http://cadd.zju.edu.cn/vgsc/免费访问，所有数据都可以XLSX/SDF文件格式下载。用户可以通过文本或结构来搜索化合物的信息，还支持高级搜索功能，实现批量查询。VGSC-DB可在http://cadd.zju.edu.cn/vgsc/免费访问，所有数据都可以XLSX/SDF文件格式下载。用户可以通过文本或结构来搜索化合物的信息，还支持高级搜索功能，实现批量查询。VGSC-DB可在http://cadd.zju.edu.cn/vgsc/免费访问，所有数据都可以XLSX/SDF文件格式下载。