Three new compounds, including a pair of chromone derivatives (1–2), and an acetophenone glucoside (3), together with three known compounds (4–6), were isolated from the mangrove endophytic fungus Mycosphaerella sp. L3A1. Their structures were elucidated by HR-ESI-MS analysis and extensive spectroscopic data. The absolute configurations of new compounds were determined using single-crystal X-ray diffraction analysis, electronic circular dichroism (ECD) calculations and chemical hydrolysis. In bioassays, compound 4 showed moderate cytotoxic activity against MDA-MB-435, HCT116, and SNB19 with IC₅₀ values in the range of 18.5-26.29 μM.

中文翻译：

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来自红树林内生真菌 Mycosphaerella sp. 的一对色素差向异构体和苯乙酮葡糖苷。L3A1

从红树林内生真菌Mycosphaerella sp.中分离出三种新化合物，包括一对色酮衍生物 ( 1-2 )和一种苯乙酮葡糖苷 ( 3 ) ，以及三种已知化合物 ( 4-6 ) 。L3A1。通过 HR-ESI-MS 分析和广泛的光谱数据阐明了它们的结构。使用单晶 X 射线衍射分析、电子圆二色性 (ECD) 计算和化学水解来确定新化合物的绝对构型。在生物测定中，化合物4对 MDA-MB-435、HCT116 和 SNB19 显示出中等的细胞毒活性，IC_{为 50}值在 18.5-26.29 μM 范围内。