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Direct determination of the π-helix structure and helix transition behavior of poly(β-phenethyl l-aspartate) via synchrotron X-ray diffraction
Journal of Peptide Science ( IF 2.1 ) Pub Date : 2022-10-23 , DOI: 10.1002/psc.3459
Hidemine Furuya 1 , Toshinari Yanagihara 1 , Yuki Orito 1 , Hiroyasu Masunaga 2
Affiliation  

The helix-sense inversions of poly(β-phenethyl l-aspartate) (2P) and diblock copolymers (2P-3P), with 2P and poly(β-phenylpropyl l-aspartate) (3P) blocks, were studied in their solid states using synchrotron wide-angle X-ray diffraction and small-angle X-ray scattering. The characteristic parameters of the π-helix structure of 2P were directly determined in situ after the helix transition at a high temperature. In the 2P-3P block copolymers, the main chains of the 3P blocks initially convert from right- to left-handed α-helices, and then the 2P blocks convert irreversibly from right-handed α-helices to left-handed π-helices. The chemical structures of the side chains of poly(l-aspartic acid ester)s significantly affect their helix transition behaviors.

中文翻译:

通过同步加速器 X 射线衍射直接测定聚(β-苯乙基 l-天冬氨酸)的 π 螺旋结构和螺旋跃迁行为

聚(β-苯乙基l -天冬氨酸)(2P)和二嵌段共聚物(2P-3P)的螺旋意义反转,2P 和聚(β-苯基丙基l -天冬氨酸)(3P)嵌段,在它们的固态下进行了研究使用同步加速器广角X射线衍射和小角度X射线散射。2P的π-螺旋结构的特征参数是在高温螺旋转变后直接原位测定的。在 2P-3P 嵌段共聚物中,3P 嵌段的主链最初从右手 α 螺旋转变为左手 α 螺旋,然后 2P 嵌段不可逆地从右手 α 螺旋转变为左手 π 螺旋。聚( l-天冬氨酸酯)侧链的化学结构显着影响其螺旋转换行为。
更新日期:2022-10-23
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