The relationship between inflammatory markers and bone turnover in adults is well known, and a negative association between cardiorespiratory fitness (CRF) and inflammatory markers has also been described. Hence, we tested whether the association between CRF and bone turnover markers is mediated by inflammatory markers in adults with metabolic syndrome. A total of 81 adults (58.5 ± 5.0 years, 62.7% women) were included in the analysis. CRF was measured by the 6-min walking test. Serum interleukin (IL)-1β, IL-6, IL-10, tumor necrosis factor alpha, high-sensitivity c-reactive protein (hsCRP) and vascular endothelial growth factor, collagen type I cross-linked C-telopeptide, procollagen type I N-terminal propeptide (P1NP), and total osteocalcin were assessed using a sensitive ELISA kit. Body composition was assessed by dual-energy X-ray absorptiometry. Partial correlation was used to test the relationship between CRF, inflammatory markers, and bone turnover markers, controlling for sex, lean mass, and fat mass. Boot-strapped mediation procedures were performed, and indirect effects with confidence intervals not including zero were interpreted as statistically significant. CRF was positively correlated with P1NP levels (r = .228, p = .044) and osteocalcin levels (r = .296, p = .009). Furthermore, CRF was positively correlated with IL-1β levels (r = .340, p = .002) and negatively correlated with hsCRP levels (r = −.335, p = .003), whereas IL-1β levels were positively correlated with P1NP levels (r = .245, p = .030), and hsCRP levels were negatively correlated with P1NP levels (r = −.319, p = .004). Finally, the association between CRF and P1NP levels was totally mediated by hsCRP (percentage of mediation = 39.9). Therefore, CRF benefits on bone formation could be dependent on hsCRP concentrations in this population.

成人炎症标志物和骨转换之间的关系是众所周知的，并且还描述了心肺健康 (CRF) 和炎症标志物之间的负相关。因此，我们测试了 CRF 和骨转换标志物之间的关联是否由患有代谢综合征的成年人的炎症标志物介导。共有 81 名成年人（58.5 ± 5.0 岁，62.7% 为女性）被纳入分析。通过 6 分钟步行测试测量 CRF。血清白细胞介素（IL）-1β、IL-6、IL-10、肿瘤坏死因子α、高敏C反应蛋白（hsCRP）和血管内皮生长因子、I型胶原交联C端肽、I型前胶原使用灵敏的 ELISA 试剂盒评估 N 末端前肽 (P1NP) 和总骨钙素。通过双能 X 射线吸收测定法评估身体成分。偏相关用于检验 CRF、炎症标志物和骨转换标志物之间的关系，控制性别、瘦体重和脂肪量。执行自举调解程序，将置信区间不包括零的间接影响解释为具有统计学意义。CRF 与 P1NP 水平呈正相关（r  = .228, p  = .044) 和骨钙素水平 ( r  = .296, p  = .009)。此外，CRF 与 IL-1β 水平呈正相关 ( r  = .340, p  = .002)，与 hsCRP 水平呈负相关 ( r  = −.335, p  = .003)，而 IL-1β 水平与P1NP 水平 ( r  = .245, p  = .030) 和 hsCRP 水平与 P1NP 水平呈负相关 ( r  = −.319, p =.004）。最后，CRF 和 P1NP 水平之间的关联完全由 hsCRP 介导（介导百分比 = 39.9）。因此，CRF 对骨形成的益处可能取决于该人群中的 hsCRP 浓度。