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TRIM-away via Gln/C-degrons
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2022-10-20 , DOI: 10.1038/s41589-022-01164-7
Qiong Guo 1, 2 , Xinyan Chen 1 , Chao Xu 1
Affiliation  

A combined structural and biochemical analysis reveals that TRIM7 E3 ligase targets viral proteins for degradation by recognizing their C-terminal glutamine (C-Gln) via its PRY-SPRY domain, providing mechanistic insight into the C-degron pathway.

中文翻译:

通过 Gln/C-degrons 进行修剪

结合结构和生化分析表明,TRIM7 E3 连接酶通过其 PRY-SPRY 结构域识别其 C-末端谷氨酰胺 (C-Gln) 来靶向降解病毒蛋白,从而提供对 C-degron 途径的机制洞察。
更新日期:2022-10-21
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