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Ulf Diederichsen (1963–2021)
Journal of Peptide Science ( IF 2.1 ) Pub Date : 2022-10-17 , DOI: 10.1002/psc.3453
Luis Moroder 1 , Norbert Sewald 2 , Annette Beck-Sickinger 3
Affiliation  

“For he was our own! … Fruitful both in counsel and deed; this we experienced and appreciated.”

With the death of Ulf Diederichsen on November 11, 2021, after a short but severe illness, we lost a great scientist in chemical biology and good friend. He was a generous and extremely gifted man whose strength was to tackle essential biological problems at a molecular level with simple model systems and to draw insightful conclusions realizing a hallmark of chemical biology by addressing biological challenges with chemical approaches derived from simple principles.

Ulf Diederichsen was born on October 7, 1963, in Munich and grew up in Göttingen, enjoying excellent scholar education at the Max-Planck Gymnasium. He moved to Freiburg im Breisgau in 1983 to study Chemistry at the Albert-Ludwigs-University. For his doctorate he moved to Zurich in 1988 to work with Prof. Eschenmoser at the ETH on the question why Nature chose pentose—but not hexose nucleic acids. He received the Dr. rer. nat. in 1993 on the Base pairing of hypoxanthine in HOMO DNA oligonucleotides and the question of the pairing behavior of glucopyranosyl oligonucleotides. He then joined the group of Prof. Dennis P. Curran at the University of Pennsylvania (Pittsburgh/USA) as postdoctoral researcher (1993–1994) investigating radical chemistry. Back to Europe he started his habilitation on “Linear nucleic acid analogues with peptidic backbones” under the mentorship of Prof. Horst Kessler at the Technical University of Munich, which was finished in 1999. He then joined the University of Würzburg as Professor of Organic Chemistry, and finally, in 2001, the University of Göttingen. He served as Dean (2005 to 2007) and Vice President for Research (2015 to 2021). In addition, he was Guest Professor at the Ludwig-Maximilians-University in Munich (1998–1999) and Goering Visiting Professor at the University of Wisconsin, USA (2000). He was elected member of the Academy of Sciences in Göttingen in 2012 and became its president in 2020.

His scientific interest was mainly centered on the non-covalent interaction of peptide helices with respect to the incorporation, organization, and dynamics in lipid membranes. He successfully employed spin-labeled peptides for distance measurements. Similarly, he addressed the membrane attachment and fusion processes of SNARE proteins with model systems (conjugates of transmembrane peptides with coiled coil peptides or peptide nucleic acids). He was interested in functionalized β-peptides as artificial matrices for aggregation and modification of model membranes. The excellent results of this outstanding research were summarized in largely over 100 publications in highly renowned international journals. Besides his exceptional scientific achievements and admirable mentorship for a large number of doctoral students and postdocs, he deserves high recognition for his excellent research management particularly as Vice President of the University of Göttingen. He also served as a highly esteemed reviewer in various panels, including the German Research Foundation. The large experience collected in this important activity, particularly also for the German peptide community, he adapted in a very successful manner also in his editorial engagement as Deputy Editor of the Journal of Peptide Science since 2012, where he was supposed to take over the full responsibility as the Editor-in-Chief from 2022.

Those of us who knew him are saddened by his sudden passing away and mourn the great loss of a dear friend and colleague. He will always be remembered as an inspiring teacher and mentor, as an enthusiastic scientist, but first and foremost as a warm and sincere human being, as a “feiner Kerl.”



中文翻译:

乌尔夫·迪德里克森 (1963–2021)

“因为他是我们自己的!……在劝告和行动上都卓有成效;这是我们经历和赞赏的。”

随着 Ulf Diederichsen 于 2021 年 11 月 11 日去世,在短暂但严重的疾病之后,我们失去了一位伟大的化学生物学科学家和好朋友。他是一个慷慨且极具天赋的人,他的优势在于用简单的模型系统在分子水平上解决基本的生物学问题,并通过从简单原理衍生的化学方法解决生物学挑战,得出有见地的结论,实现化学生物学的标志。

Ulf Diederichsen 于 1963 年 10 月 7 日出生于慕尼黑,在哥廷根长大,在马克斯-普朗克体育馆接受了优秀的学者教育。1983 年,他搬到弗莱堡,在阿尔伯特路德维希大学学习化学。为了获得博士学位,他于 1988 年移居苏黎世,与 ETH 的 Eschenmoser 教授一起研究为什么 Nature 选择戊糖而不是己糖核酸的问题。他收到了博士rer。自然。1993年关于HOMO DNA寡核苷酸中次黄嘌呤的碱基配对和吡喃葡萄糖基寡核苷酸的配对行为问题. 然后,他加入宾夕法尼亚大学(匹兹堡/美国)的 Dennis P. Curran 教授小组,担任博士后研究员(1993-1994)研究自由基化学。回到欧洲,他在慕尼黑工业大学霍斯特·凯斯勒教授的指导下开始了“具有肽骨架的线性核酸类似物”的适应期,并于 1999 年完成。随后他加入维尔茨堡大学担任有机化学教授,最后,在 2001 年,哥廷根大学。他曾担任院长(2005 年至 2007 年)和研究副总裁(2015 年至 2021 年)。此外,他还是慕尼黑路德维希马克西米利安大学的客座教授(1998-1999 年)和美国威斯康星大学的戈林客座教授(2000 年)。

他的科学兴趣主要集中在肽螺旋在脂质膜中的掺入、组织和动力学方面的非共价相互作用。他成功地使用自旋标记肽进行距离测量。同样,他用模型系统(跨膜肽与卷曲肽或肽核酸的缀合物)解决了 SNARE 蛋白的膜附着和融合过程。他对功能化的 β-肽作为用于聚集和修饰模型膜的人工基质感兴趣。这项杰出研究的卓越成果在国际知名期刊的 100 多篇出版物中得到了总结。除了他卓越的科学成就和对大量博士生和博士后的令人钦佩的指导外,作为哥廷根大学的副校长,他出色的研究管理值得高度认可。他还曾在包括德国研究基金会在内的多个小组中担任备受尊敬的审稿人。在这项重要活动中积累的大量经验,特别是对于德国肽界而言,他也以非常成功的方式适应了他作为副主编的编辑参与自 2012 年起担任《Journal of Peptide Science》,他本应从 2022 年起担任主编的全部职责。

我们这些认识他的人都对他的突然去世感到难过,并为失去一位亲爱的朋友和同事而哀悼。他将永远被人们铭记为一位鼓舞人心的老师和导师,一位热情的科学家,但首先是一位热情而真诚的人,一位“feiner Kerl”。

更新日期:2022-10-17
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