Methods for the modification of indole derivatives are powerful techniques in organic, medicinal, and biomolecular chemistry. Here, we report a protocol for the C–H alkenylation of N–H indoles with β-chlorovinyl dithianes to furnish alkenyl indoles through dual 1,3-sulfur rearrangements. This alkenylation protocol could selectively prepare a variety of vinyl indoles in moderate to high yields with excellent functional group tolerance.

中文翻译：

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通过双 1,3-硫迁移过程对吲哚进行 C-H 烯基化

吲哚衍生物的改性方法是有机、药物和生物分子化学中的强大技术。在这里，我们报告了 N-H 吲哚与 β-氯乙烯基二噻吩的 C-H 烯基化方案，以通过双 1,3-硫重排提供烯基吲哚。这种烯基化方案可以选择性地制备多种乙烯基吲哚，以中等至高产率，具有优异的官能团耐受性。