A recent study by Missiaen et al (2022) uncovers hepatocellular carcinoma (HCC) cells to downregulate urea cycle enzymes and rely on the uptake of exogenous arginine and GCN2 kinase-dependent cell-cycle arrest for survival. These results offer new avenues for combinatorial targeting of liver cancer.

中文翻译：

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让肝癌细胞变得ARGH！

Missiaen等人(2022)最近的一项研究发现，肝细胞癌 (HCC) 细胞下调尿素循环酶，并依赖外源精氨酸的摄取和 GCN2 激酶依赖性细胞周期停滞来生存。这些结果为肝癌的组合靶向提供了新途径。