Biosynthetic elucidation and structural revision of the fungal meroterpenoid brevione E were achieved. The brevione E pathway involves dihydrotropone synthesis via the α-ketoglutarate-dependent dioxygenase BrvJ. BrvJ is also the key enzyme responsible for the pathway branching from setosusin biosynthesis, which involves a BrvJ homologue, SetK. Amino acid residues that account for their product selectivity were also identified.

中文翻译：

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Brevione E 的生物合成阐明和结构修正：Setosusin 生物合成途径分支的关键双加氧酶的表征

实现了真菌类萜类短酮 E 的生物合成阐明和结构修正。brevione E 途径涉及通过 α-酮戊二酸依赖性双加氧酶 BrvJ 合成二氢托酮。BrvJ 也是负责从 setosusin 生物合成分支途径的关键酶，该途径涉及 BrvJ 同系物 SetK。还鉴定了解释其产物选择性的氨基酸残基。