Purpose

To investigate whether the quality of cartilage repair tissue is associated with patellofemoral osteoarthritis (PFOA) at a three year follow-up after matrix-induced autologous chondrocyte implantation (MACI).

Methods

This retrospective study included 32 patients who underwent MACI between October 2014 and May 2018 at our institute. The Lysholm score and Visual Analog Scale (VAS) score were assessed. The magnetic resonance observation of cartilage repair tissue (MOCART) 2.0 score and T2* relaxation time of repair tissue were used to evaluate cartilage repair tissue quality. A modified MRI Osteoarthritis Knee Score (mMOAKS) was used to evaluate PFOA.

Results

Compared with pre-operative scores, the final Lysholm score (50.71 ± 2.22 vs 89.70 ± 1.18; t = 15.5, P < 0.0001) and VAS score (4.67 ± 0.47 vs 0.92 ± 0.64; t = 22.62, P < 0.0001) were improved at 3 years after MACI. At the three year follow-up, the mean MOCART 2.0 score was 61.56 ± 18.11, and the T2* relaxation time of the repair tissue was significantly lower than that in the healthy control region (24.11 ± 6.38 vs 34.39 ± 1.33, t = − 8.635, P < 0.0001). The mean mMOAKS score was 9.16 ± 4.51. On univariate analysis, the MOCART 2.0 score and T2* relaxation time were negatively associated with the mMOAKS score.

Conclusion

MACI can lead to significant pain relief and restoration of knee joint function, and good quality cartilage repair tissue was a protective factor against PFOA at the three year follow-up.

中文翻译：

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基质诱导自体软骨细胞植入三年随访后软骨修复组织质量与髌股骨关节炎的相关性：一项横断面研究

目的

基质诱导自体软骨细胞植入（MACI）后三年随访，研究软骨修复组织的质量是否与髌股骨关节炎（PFOA）相关。

方法

这项回顾性研究纳入了 2014 年 10 月至 2018 年 5 月期间在我们研究所接受 MACI 的 32 名患者。评估 Lysholm 评分和视觉模拟量表 (VAS) 评分。采用软骨修复组织磁共振观察（MOCART）2.0评分和修复组织T2*弛豫时间评价软骨修复组织质量。使用改良的 MRI 骨关节炎膝关节评分 (mMOAKS) 来评估 PFOA。

结果

与术前相比，最终Lysholm评分（50.71±2.22 vs 89.70±1.18；t  = 15.5，P  < 0.0001）和VAS评分（4.67±0.47 vs 0.92±0.64；t  = 22.62，P  < 0.0001）均有所改善MACI 后 3 年。三年随访时，MOCART 2.0 平均评分为 61.56 ± 18.11，修复组织的 T2* 弛豫时间显着低于健康对照区（24.11 ± 6.38 vs 34.39 ± 1.33，t =  − 8.635，P  < 0.0001）。平均 mMOAKS 评分为 9.16 ± 4.51。单变量分析显示，MOCART 2.0 评分和 T2* 弛豫时间与 mMOAKS 评分呈负相关。

结论

MACI 可以显着缓解疼痛并恢复膝关节功能，并且在三年的随访中，优质的软骨修复组织是对抗 PFOA 的保护因素。