Kendrick and Collinson suggest that we overstepped the data in discussion of the relevance of our serotonin paper to antidepressant use.12 The serotonin hypothesis was propagated by drug companies and academics as a rationale for why people should take antidepressants. It is still widely disseminated,3 but the evidence is unconvincing. No other biological hypotheses for depression are proved or accepted.4 If there is no conclusive evidence that antidepressants work by reversing an underlying abnormality, we must consider other plausible explanations for how they might …

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为什么讨论抗抑郁药的作用很重要

肯德里克和科林森建议我们在讨论我们的血清素论文与抗抑郁药使用的相关性时超越了数据。12 血清素假说被制药公司和学者宣传为人们应该服用抗抑郁药的理由。它仍在广泛传播，3 但证据缺乏说服力。没有其他关于抑郁症的生物学假设被证明或接受。4 如果没有确凿的证据表明抗抑郁药通过逆转潜在异常起作用，我们必须考虑其他合理的解释来解释它们如何……