We present a thermodynamically consistent model describing the dynamics of a multicomponent mixture where one enzyme component catalyzes a reaction between other components. We find that the catalytic activity alone can induce phase separation for sufficiently active systems and large enzymes, without any equilibrium interactions between components. In the limit of fast reaction rates, binodal lines can be calculated using a mapping to an effective free energy. We also explain how this catalysis-induced phase separation can act to autoregulate the enzymatic activity, which points at the biological relevance of this phenomenon.

中文翻译：

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催化诱导的相分离和酶活性的自动调节

我们提出了一个热力学一致的模型来描述多组分混合物的动力学，其中一种酶组分催化其他组分之间的反应。我们发现单独的催化活性可以诱导足够活跃的系统和大型酶的相分离，而组分之间没有任何平衡相互作用。在快速反应速率的限制下，可以使用映射到有效自由能来计算双节线。我们还解释了这种催化诱导的相分离如何自动调节酶活性，这表明了这种现象的生物学相关性。