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Association between urinary bisphenol analogue concentrations and lung cancer in adults: A case-control study
Environmental Pollution ( IF 8.9 ) Pub Date : 2022-09-30 , DOI: 10.1016/j.envpol.2022.120323
Jianli Qu 1 , Weili Mao 2 , Kaizhen Liao 1 , Yingying Zhang 1 , Hangbiao Jin 3
Affiliation  

Elevated urinary bisphenol A (BPA) concentrations have been associated with lung cancer in humans. However, toxicological studies demonstrated that the proliferation of lung cancer cells was inhibited by BPA exposure. Therefore, it is still necessary to determine whether exposure to BPA and other bisphenol analogues (BPs) is associated with lung cancer in humans. In this study, 226 lung cancer patients and 243 controls were randomly recruited. Concentrations of three BPs in human urine were quantified and their relationships with the risk of human lung cancer were evaluated. BPA (mean 1.03 ng/mL, 0.87 μg/g Cre) was the predominant BP in human urine, followed by bisphenol S (BPS) (0.72 ng/mL, 0.53 μg/g Cre) and bisphenol F (0.32 ng/mL, 0.37 μg/g Cre). Significant correlations between creatinine-corrected urinary BPA concentrations and the lung cancer risk (odds ratio (OR) adjusted = 1.28, 95% confidence interval (CI): 1.17, 1.40; Ptrend = 0.04) were found using logistical regression analysis. Creatinine-corrected urinary concentrations of BPS in participants showed significant correlations with lung cancer (ORadjusted = 1.23, 95% CI: 1.04, 1.59; Ptrend = 0.01) in the adjusted model. In the stratification analysis, the significant correlation between urinary creatinine-corrected concentrations of BPA and the risk of lung cancer still observed in male participants (OR = 1.36, 95% CI: 1.09, 1.62, p = 0.040). This study demonstrates that elevated human exposure to BPA and BPS may be associated with the increased lung cancer risk.



中文翻译:

成人尿双酚类似物浓度与肺癌的关系:病例对照研究

升高的尿双酚 A (BPA) 浓度与人类肺癌有关。然而,毒理学研究表明,肺癌细胞的增殖受到 BPA 暴露的抑制。因此,仍然有必要确定暴露于 BPA 和其他双酚类似物 (BPs) 是否与人类肺癌有关。在这项研究中,随机招募了 226 名肺癌患者和 243 名对照。量化了人类尿液中三种 BP 的浓度,并评估了它们与人类肺癌风险的关系。BPA(平均 1.03 ng/mL,0.87 μg/g Cre)是人类尿液中的主要 BP,其次是双酚 S(BPS)(0.72 ng/mL,0.53 μg/g Cre)和双酚 F(0.32 ng/mL, 0.37 微克/克 Cre)。调整后 = 1.28, 95% 置信区间 (CI):1.17, 1.40; 使用逻辑回归分析发现P趋势= 0.04)。在校正模型中,参与者中经肌酐校正的 BPS 尿浓度与肺癌显着相关(OR校正 = 1.23, 95% CI:1.04, 1.59;P趋势 = 0.01)。在分层分析中,在男性参与者中仍观察到经尿肌酐校正的 BPA 浓度与肺癌风险之间的显着相关性(OR = 1.36, 95% CI: 1.09, 1.62, p  = 0.040)。这项研究表明,人类对 BPA 和 BPS 的暴露量增加可能与肺癌风险增加有关。

更新日期:2022-09-30
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