Ecotoxicological effects of photolytic degradation mixtures of the two brominated flame retardants PolymericFR and Tetrabromobisphenol A-bis (2,3-dibrom-2-methyl-propyl) Ether (TBBPA-BDBMPE) have been studied in vitro and in vivo. Both substances were experimentally degraded separately by exposure to artificial UV-light and the resulting degradation mixtures from different time points during the UV-exposure were applied in ecotoxicological tests. The in vitro investigation showed no effects of the degraded flame retardants on the estrogenic and androgenic receptors via the CALUX (chemically activated luciferase gene expression) assay. Short-term exposures (up to 96 h) of Lumbriculus variegatus lead to temporary physiological reactions of the annelid. The exposure to degraded PolymericFR lead to an increased activity of Catalase, while the degradation mixture of TBBPA-BDBMPE caused increases of Glutathione-S-transferase and Acetylcholine esterase activities. Following a chronic exposure (28 d) of L. variegatus, no effects on the growth, reproduction, fragmentation and energy storage of the annelid were detected. The results indicate that the experimental degradation of the two flame retardants causes changes in their ecotoxicological potential. This might lead to acute physiological effects on aquatic annelids, which, however, do not affect the animals chronically according to our results.

已在体外和体内研究了两种溴化阻燃剂 PolymericFR 和四溴双酚 A-双（2,3-二溴-2-甲基-丙基）醚 (TBBPA-BDBMPE) 的光解降解混合物的生态毒理学效应。两种物质通过暴露于人造紫外线分别进行实验降解，并将在紫外线暴露期间不同时间点产生的降解混合物应用于生态毒理学测试。通过CALUX（化学激活的荧光素酶基因表达）测定，体外研究显示降解的阻燃剂对雌激素和雄激素受体没有影响。Lumbriculus variegatus的短期暴露（长达 96 小时）导致环节动物的暂时性生理反应。暴露于降解的 PolymericFR 导致过氧化氢酶的活性增加，而 TBBPA-BDBMPE 的降解混合物导致谷胱甘肽-S-转移酶和乙酰胆碱酯酶的活性增加。在长期暴露（28 天）L. variegatus后，未检测到对环节动物的生长、繁殖、破碎和能量储存的影响。结果表明，两种阻燃剂的实验降解导致其生态毒理学潜力发生变化。这可能会导致对水生环节动物的急性生理影响，然而，根据我们的结果，这不会长期影响动物。