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Organoids as tools for fundamental discovery and translation—a Keystone Symposia report
Annals of the New York Academy of Sciences ( IF 5.2 ) Pub Date : 2022-09-30 , DOI: 10.1111/nyas.14874
Jennifer Cable 1 , Matthias P Lutolf 2, 3, 4 , Jianping Fu 5, 6, 7 , Sunghee Estelle Park 8 , Athanasia Apostolou 9, 10 , Shuibing Chen 11 , Cheng Jack Song 12 , Jason R Spence 13 , Prisca Liberali 14 , Madeline Lancaster 15 , Anna B Meier 16 , Nicole Min Qian Pek 17, 18, 19 , James M Wells 17, 20 , Meghan M Capeling 21 , Ana Uzquiano 22, 23 , Samira Musah 24, 25, 26, 27 , Meritxell Huch 28 , Mina Gouti 29 , Pleun Hombrink 30 , Giorgia Quadrato 31 , Jean-Paul Urenda 31
Affiliation  

Complex three-dimensional in vitro organ-like models, or organoids, offer a unique biological tool with distinct advantages over two-dimensional cell culture systems, which can be too simplistic, and animal models, which can be too complex and may fail to recapitulate human physiology and pathology. Significant progress has been made in driving stem cells to differentiate into different organoid types, though several challenges remain. For example, many organoid models suffer from high heterogeneity, and it can be difficult to fully incorporate the complexity of in vivo tissue and organ development to faithfully reproduce human biology. Successfully addressing such limitations would increase the viability of organoids as models for drug development and preclinical testing. On April 3–6, 2022, experts in organoid development and biology convened at the Keystone Symposium “Organoids as Tools for Fundamental Discovery and Translation” to discuss recent advances and insights from this relatively new model system into human development and disease.

中文翻译:

类器官作为基础发现和翻译的工具——Keystone Symposia 报告

复杂的三维体外器官模型或类器官提供了一种独特的生物学工具,与过于简单的二维细胞培养系统和过于复杂且可能无法概括的动物模型相比具有明显的优势人体生理学和病理学。尽管仍然存在一些挑战,但在驱动干细胞分化成不同类器官类型方面已经取得了重大进展。例如,许多类器官模型存在高度异质性,很难完全融入体内的复杂性组织和器官的发育,以忠实地再现人类生物学。成功解决这些限制将提高类器官作为药物开发和临床前测试模型的可行性。2022 年 4 月 3 日至 6 日,类器官发育和生物学专家召开了“类器官作为基础发现和转化工具”的 Keystone 研讨会,讨论了这一相对较新的模型系统在人类发育和疾病方面的最新进展和见解。
更新日期:2022-09-30
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